Thermo Scientific™ Accucore™ UHPLC and HPLC columns


Thermo Scientific™ Accucore™ columns are based on solid core (superficially porous) particles yielding highly efficient, rugged separations for high performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) applications. They offer lower backpressures than fully porous sub-2 µm particles. These are the columns of choice when sample volumes are limited, or when higher throughput is desired. We offer the widest portfolio of solid core chemistries (1.5, 2.6, 4 µm), which benefits you with options to optimize your resolution and separations.


Selectivity Functionality Description
Reversed-phase hydrophobic interaction  of nonpolar compounds (reversed-phase) C30 Designed for separating hydrophobic long chain, structurally related isomers
C18 Excellent peak shape for hydrophobic interaction
C8 Similar selectivity to C18 but with less retention
C4 Short alkyl chain length, low hydrophobicity column for less retention than C18 or C8
RP/MS Optimized for MS detection
Reversed-phase with enhanced hydrolytic stability aQ Polar endcapped C18 are stable in 100% aqueous mobile phases and provide enhanced retention and resolution of polar analytes
Polar premium Amide-embedded functional group
Reversed-phase with selectivity for aromatic compounds PFP: Alternative selectivity in reverse phase applications. The fluorine atoms around the phenyl ring enhance pi-pi interactions with aromatic molecules, including hologenated compounds
pentafluoro- phenyl
Phenyl Alternative selectivity in reverse phase applications, particularly for aromatic compounds
Phenyl-Hexyl Unique selectivity for aromatic and moderately polar analytes
Biphenyl Enhanced pi-pi interactions with aromatics, and separation of critical pairs and isomers
Normal phase of non- polar and moderately polar organic compounds Silica Unbonded silica
HILIC; enhanced retention of polar and hydrophilic compounds Urea-HILIC Urea functional group
Amide-HILIC Amide functional group