Corning® Supersomes™ – Human P450 Enzymes

$1.00

Description

Corning Supersomes Enzymes are recombinant enzyme products and recognized worldwide as the industry gold standard. These enzymes are prepared from baculovirus-transfected insect cells with very high levels of catalytic activities (typically 6-fold higher than an average HLM sample). This is ideal for screening high throughput drug interactions, studying slowly metabolized chemicals, or manufacturing large-scale production of metabolites for structural identification.

Corning offers more than 40 different human and animal P450 isoforms, many with or without NADPH reductase. Additionally, Corning offers wide range of non-P450 metabolic enzymes, including UDP-glucuronosyl transferases (UGTs), flavin-containing monooxygenases (FMOs), monoamine oxidases (MAOs), soluble N-Acetyltransferases (NATs), and carboxylesterases (CESs). For many of the recombinant enzyme products, side-by-side comparisons of the catalytic activity with pooled human liver microsomes (HLMs) have been performed and the data are available by email [email protected]

br>Key Benefits

  • Wide-range selection of high quality metabolism enzymes
  • Higher catalytic activities than the native enzymes from human liver and other organs, with comparable Km
  • Accepted industry gold standard recombinant enzyme system, with large number of peer-reviewed publications
  • Preferred enzymes for generating data to use with the Simcyp computational model
  • Supports essential assays such as reaction phenotyping, metabolic stability, and enzyme inhibition required for FDA new drug registration and other pharmacokinetic studies that are appropriate for evaluating pro-drugs and CYP or non-CYP pathways of elimination.

 

Cat. No. Product Name
456202 Corning® Supersomes™ Human CYP3A4 + Oxidoreductase + b5, 0.5 nmol
456203 Corning® Supersomes™ Human CYP1A2 + Oxidoreductase, 0.5 nmol
456204 Corning® Supersomes™ Human CYP2A6 + Oxidoreductase, 1 nmol
456206 Corning® Supersomes™ Human CYP2E1 + Oxidoreductase + b5, 1 nmol
456207 Corning® Supersomes™ Human CYP3A4 + Oxidoreductase, 1 nmol
456210 Corning® Supersomes™ Human CYP2B6 + Oxidoreductase, 0.5 nmol
456212 Corning® Supersomes™ Human CYP2C8 + Oxidoreductase, 1.0 nmol
456217 Corning® Supersomes™ Human CYP2D6*1 (Val374) + Oxidoreductase, 0.5 nmol
456218 Corning® Supersomes™ Human CYP2C9*1 (Arg144) + Oxidoreductase, 1 nmol
456219 Corning® Supersomes™ Human CYP2C19 + Oxidoreductase, 0.5 nmol
456220 Corning® Supersomes™ Human CYP1B1 + Oxidoreductase, 0.5 nmol
456221 Corning® Supersomes™ Human CYP4A11 + Oxidoreductase, 0.5 nmol
456222 Corning® Supersomes™ Human CYP2C18 + Oxidoreductase, 0.5 nmol
456235 Corning® Supersomes™ Human CYP3A5 + Oxidoreductase, 1 nmol
456237 Corning® Supersomes™ Human CYP3A7 + Oxidoreductase + b5, 0.5 nmol
456254 Corning® Supersomes™ Human CYP2A6 + Oxidoreductase + b5, 0.5 nmol
456255 Corning® Supersomes™ Human CYP2B6 + Oxidoreductase + b5, 0.5 nmol
456256 Corning® Supersomes™ Human CYP3A5 + Oxidoreductase + b5, 0.5 nmol
456258 Corning® Supersomes™ Human CYP2C9*1 (Arg144) + Oxidoreductase + b5, 0.5 nmol
456259 Corning® Supersomes™ Human CYP2C19 + Oxidoreductase + b5, 0.5 nmol
456260 Corning® Supersomes™ Human CYP19 (Aromatase) + Oxidoreductase, 0.5 nmol
456264 Corning® Supersomes™ Human CYP2J2 + Oxidoreductase + b5, 0.5 nmol
456272 Corning® Supersomes™ Human CYP4F2 + Oxidoreductase + b5, 0.5 nmol
456273 Corning® Supersomes™ Human CYP4F3A + Oxidoreductase +b5, 0.25 nmol
456274 Corning® Supersomes™ Human CYP4F3B + Oxidoreductase + b5, 0.5 nmol
456275 Corning® Supersomes™ Human CYP4F12 + Oxidoreductase + b5, 0.5 nmol
Corning® Supersomes™ – Human P450 Enzymes
$1.00