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Real Time PCR and Sequencing for Infectious Disease

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Real Time PCR

EBV ASR

CMV ASR

Real Time HIV-1

Sequencing

ViroSeq HIV-1 Genotyping System

Real Time PCR Instrumentation

m2000 Molecular Testing System

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The Abbott RealTime HIV-1 assay is an in vitro reverse transcription-polymerase chain reaction (RT-

PCR) assay for the quantitation of Human Immunodeficiency Virus type 1 (HIV-1) on the automated m

2000 System in human plasma from HIV-1 infected individuals over the range of 40 to 10,000,000

copies/mL.

The Abbott RealTime HIV-1 assay is intended for use in conjunction with clinical presentation

and other laboratory markers for disease prognosis and for use as an aid in assessing viral response to

antiretroviral treatment as measured by changes in plasma HIV-1 RNA levels.

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The ViroSeq HIV-1 Genotyping System is intended for use in detecting HIV genomic mutations that confer

resistance to specific types of antiretroviral drugs, as an aid in monitoring and treating HIV infection.

Specifically, the ViroSeq HIV-1 Genotyping System can be used to:

• Detect HIV-1 Subtype B viral resistance in plasma samples collected in EDTA with a viral load ranging from 2000 to 750,000 copies/mL
• Genotype the entire HIV-1 protease gene from codons 1-99 and two-thirds of the reverse transcriptase (RT) gene from codons 1-335

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m2000 Molecular Testing System

• By reducing manual processing steps during molecular testing, the m2000 system can help deliver test results for patients with life-threatening diseases faster, improving medical care through earlier intervention.

• Using sophisticated computer software, the Abbott m2000 automated instrument system accurately detects and measures life-threatening viruses and bacteria in patient samples in less than five hours, a significant reduction from other testing methods that may take up to two days.

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